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A disadvantage of using an attenuated live microbe in a vaccine is that it can conceivably mutate back to a virulent strain.

A) True
B) False

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Human B lymphocytes mature in an intestinal region called the bursa.

A) True
B) False

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Reliable vaccines exist for all of the following diseases except


A) malaria.
B) botulism.
C) cholera.
D) yellow fever.
E) rabies.

F) B) and D)
G) A) and B)

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Discuss, in detail, all the genetic and cellular events encompassed in the clonal selection theory of lymphocyte development.

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The clonal selection theory of lymphocyt...

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All of the following characterize the secondary response to an antigen except


A) a higher titer of antibody is produced than the primary response.
B) a longer persistence of antibody than with the primary response.
C) a quicker rate of antibody synthesis than the primary response.
D) it is mostly IgM antibodies that are produced.
E) it is also known as the anamnestic response.

F) A) and B)
G) All of the above

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The immunoglobulin class that is the only one capable of crossing the placenta is


A) IgA.
B) IgD.
C) IgE.
D) IgG.
E) IgM.

F) D) and E)
G) None of the above

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Discuss the various ways by which antibodies interact with antigen and facilitate antigen inhibition or destruction.

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Antibodies interact with antigens in var...

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Describe the characteristics that distinguish the following: a) antigen, b) hapten, c) antigenic determinant, d) alloantigen, e) heterophilic antigen, and f) autoantigen.

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a) Antigen: An antigen is a substance th...

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In the primary response to an antigen, the first class of antibody to be secreted is


A) IgD.
B) IgE.
C) IgG.
D) IgM.
E) IgA.

F) C) and E)
G) A) and D)

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The process of clonal deletion is designed to


A) destroy clones of lymphocytes able to react to self molecules.
B) slow down the primary immune response to an antigen.
C) slow down the secondary immune response to an antigen.
D) limit the number of lymphocyte clones an individual has in order to make the system more efficient.
E) slow down the immune system in the elderly.

F) D) and E)
G) All of the above

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Herceptin is an example of a monoclonal antibody-based drug for


A) asthma.
B) crohn's disease.
C) breast cancer.
D) respiratory syncytial virus.
E) All of these choices are correct.

F) C) and E)
G) A) and D)

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Which of the immunizations would carry the greatest risk for immunocompromised patients?


A) killed, inactivated vaccines
B) attenuated vaccines
C) toxoids
D) immune serums
E) subunit vaccines

F) B) and D)
G) D) and E)

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Which antibody confers the most important specific local immunity to enteric, respiratory, and genitourinary pathogens?


A) IgD
B) IgE
C) IgG
D) IgM
E) IgA

F) A) and C)
G) D) and E)

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Natural killer NK) cells recognize and identify their targets in an immunologically nonspecific way, but then kill their targets in a manner very similar to that of TC cells.

A) True
B) False

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Alloantigens are the basis for an individual's blood group and MHC profile.

A) True
B) False

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Which kind of T-cell synthesizes perforins and granzymes to destroy viral infected cells, and cancer cells?


A) TC
B) TH
C) CD4
D) MHC

E) A) and B)
F) All of the above

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Post-exposure prophylaxis for rabies includes shots of HRIG human rabies immune globulin) and rabies vaccine. The HRIG provides ________________ whereas the vaccine promotes the development of _______________.


A) artificial passive immunity; natural active immunity
B) artificial passive immunity; artificial active immunity
C) natural passive immunity; artificial passive immunity
D) artificial active immunity; artificial passive immunity
E) artificial active immunity; natural active immunity

F) A) and B)
G) C) and D)

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Helper T-cells


A) secrete antibodies.
B) function in allergic reactions.
C) directly destroy target cells.
D) suppress immune reactions.
E) activate B-cells and other T-cells.

F) C) and D)
G) A) and B)

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All of the following may be targeted by TC cells, except


A) viral-infected host cells.
B) cancer cells.
C) invading bacterial cells.
D) cells in transplanted tissue from an imperfectly matched donor.
E) All of these cells could be targeted by Tc cells.

F) B) and E)
G) A) and E)

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An example of natural passive immunity would be


A) chickenpox infection is followed by lifelong immunity.
B) chickenpox vaccine triggers extended immunity to chickenpox.
C) giving a person immune serum globulins to chickenpox virus after exposure to the disease.
D) a fetus acquiring maternal IgG to the chickenpox virus across the placenta.

E) C) and D)
F) None of the above

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