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The following fatty acid __________ be metabolized by _.  The following fatty acid __________ be metabolized by _.   A)  will; being run through the  \beta -oxidation pathway until the double bond is isomerized for the pathway to continue B)  will not; not being recognized by  \beta -oxidation pathway enzymes C)  will not; entering the pathway as normal but eventually inhibiting the enzymes D)  will; being run through the  \beta -oxidation pathway as normal


A) will; being run through the β\beta -oxidation pathway until the double bond is isomerized for the pathway to continue
B) will not; not being recognized by β\beta -oxidation pathway enzymes
C) will not; entering the pathway as normal but eventually inhibiting the enzymes
D) will; being run through the β\beta -oxidation pathway as normal

E) None of the above
F) B) and C)

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How many more enzymes does the oxidation of oleoyl-CoA (18:1) require than the oxidation of stearoyl-CoA (18:0) ?


A) 0
B) 1
C) 2
D) 3

E) None of the above
F) A) and D)

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In order for a fatty acyl-CoA to be moved into the mitochondria for β\beta -oxidation, it must be


A) transported by the carnitine-acylcarnitine translocase.
B) activated by ATP.
C) reduced by NADH and FADH2.
D) hydrolyzed into acetyl-coA fragments.

E) A) and B)
F) B) and C)

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Which one of the following lipoproteins functions to transport cholesterol from the peripheral tissues to the liver?


A) VLDL
B) LDL
C) HDL
D) chylomicron

E) A) and B)
F) All of the above

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What enzyme is activated by HDL to release cholesterol from the cell membranes of peripheral tissues?


A) phosphatidylcholine esterase
B) HDL apolipase
C) cholesterol esterase
D) lecithin-cholesterol acyltransferase

E) B) and C)
F) A) and D)

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For every two carbons that are added to a growing fatty acid chain in the fatty acid synthesis pathway, __________ ATPs and __________ NADPHs are required.


A) 0; 1
B) 1; 2
C) 2; 1
D) 0; 2

E) A) and B)
F) C) and D)

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Diagram the process by which the palmitoyl-CoA molecule moves from the cytosol into the mitochondria for degradation.

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What enzyme class catalyzes the following reaction? What enzyme class catalyzes the following reaction?   A)  ligase B)  hydratase C)  transferase D)  oxidoreductase


A) ligase
B) hydratase
C) transferase
D) oxidoreductase

E) A) and C)
F) C) and D)

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The acetyl-CoA for fatty acid synthesis comes from the


A) breakdown of fats.
B) TCA cycle.
C) mitochondria via the citrate shuttle.
D) breakdown of cytoplasmic pyruvate.

E) A) and D)
F) None of the above

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C

All of the following are metabolic fates of cholesterol EXCEPT


A) the majority of cholesterol is catabolized to bile salts.
B) cholesterol may be present in membranes.
C) cholesterol is a precursor for nucleotides.
D) steroids are derived from cholesterol.

E) A) and D)
F) B) and C)

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The smallest precursor molecule cholesterol is derived from


A) squalene.
B) isoprene.
C) arachidonic acid.
D) acetyl-CoA.

E) A) and D)
F) None of the above

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All of the following genes are activated by the interaction of the SREBP with the SRE, EXCEPT for


A) HMG-CoA reductase.
B) LDL receptor.
C) HMG-CoA synthase.
D) cholesterol esterase.

E) A) and D)
F) B) and C)

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D

What cofactor, common to carboxylase enzymes, is used by acetyl-CoA carboxylase?


A) NADPH
B) FAD
C) biotin
D) pyridoxal phosphate

E) C) and D)
F) A) and D)

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Describe the metabolic conditions under which ketone bodies are produced.

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When carbohydrate levels run low, typica...

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Identify the molecular components of the following lipoprotein. Identify the molecular components of the following lipoprotein.

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(A) Cholesterol, (B) triacylgl...

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During the conversion of VLDL to IDL, the


A) IDL becomes increasingly enriched in cholesterol.
B) core of IDL becomes increasingly enriched in TAGs.
C) LDL intermediate is formed.
D) IDL becomes depleted in protein.

E) None of the above
F) C) and D)

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Which is true of the acyl carrier protein (ACP) ?


A) It transports the fatty acid chain during oxidation and synthesis.
B) It directs the growing fatty acid chain from one enzyme active site to another in the fatty acid synthesis pathway.
C) It requires ATP for proper function.
D) It catalyzes the delivery of fatty acyl chains from the mitochondria to the cytosol.

E) C) and D)
F) A) and D)

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What is the name of the enzyme that adds another carbon atom to propionyl-CoA in the degradation of odd-chain fatty acids?

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Propionyl-CoA carboxylase

Cholesterol biosynthesis and cholesterol uptake is stimulated by


A) the binding of SREs to cholesterol uptake genes.
B) the binding of SREBPs to SREs and activating the transcription of cholesterol synthesizing genes.
C) increased levels of cholesterol binding to the SREBPs.
D) the uptake of LDLs through the LDL receptor.

E) A) and B)
F) None of the above

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How many more passes through β\beta -oxidation does the saturated fat stearic acid (18:0) require, compared with the monounsaturated fat oleic acid (18:1) ?


A) 0
B) 1
C) 2
D) 17

E) A) and D)
F) A) and C)

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