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Human cells can produce many more proteins that the number of genes present in the genome.Describe two mechanisms that help to explain this difference.

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During processing of pre-mRNA in the nuc...

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MATCHING Match the appropriate term with the description. -LINE 1 sequences


A) Technique used to determine the location of a gene
B) Particular genes are often inherited jointly
C) Provides clues to the location of genes
D) A collection of DNA sequences that represents all regions of the genome
E) DNA sequences that are useful for identifying the positions of genes
F) Repetitive DNA with the ability to replicate and move around the genome
G) Map units of linkage maps
H) Repetitive sequences that are thought to have played an important role in human evolution
I) Genetic exchange between chromosomes
J) Repetitive sequences comprising about 17% of the genome

K) A) and D)
L) None of the above

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It is easier to map genes on the autosomes than on the sex chromosomes.

A) True
B) False

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Positional cloning


A) uses random cloning to isolate genes.
B) starts by sequencing the entire chromosome containing the gene of interest.
C) makes use of particular markers on the DNA.
D) makes use of the location of Alu sequences.
E) All of these are correct answers

F) B) and E)
G) A) and B)

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In 1990,a young girl was treated for severe combined immunodeficiency disorder.Her treatment involved


A) genetic modification of red blood cells removed from her body.
B) insertion of the adenosine deaminase gene into her white blood cells while they were present in her body.
C) injection of adenosine deaminase protein.
D) insertion of the RPE65 allele into her cells.
E) insertion of the adenosine deaminase gene into white blood cells removed from her body.

F) A) and B)
G) A) and C)

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This is a collection of DNA fragments that contains all the sequences in a genome.


A) linkage library
B) exome library
C) repetitive DNA library
D) positional library
E) genomic library

F) C) and D)
G) B) and E)

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MATCHING Match the appropriate term with the description. -Positional cloning


A) Technique used to determine the location of a gene
B) Particular genes are often inherited jointly
C) Provides clues to the location of genes
D) A collection of DNA sequences that represents all regions of the genome
E) DNA sequences that are useful for identifying the positions of genes
F) Repetitive DNA with the ability to replicate and move around the genome
G) Map units of linkage maps
H) Repetitive sequences that are thought to have played an important role in human evolution
I) Genetic exchange between chromosomes
J) Repetitive sequences comprising about 17% of the genome

K) A) and J)
L) A) and B)

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All of an organism's genetic information is contained in its


A) DNA profile.
B) genome.
C) mtDNA.
D) proteins.
E) exome.

F) B) and C)
G) A) and E)

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Describe how an Alu sequence insertion may have played a role in human evolution.

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Although Alu sequences may pose a threat...

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The functions of almost all of the human genes are currently known.

A) True
B) False

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Gene therapy typically involves all of the following EXCEPT


A) genetically modified viruses.
B) the transfer of functional genes into cells.
C) growth of modified cells in the lab.
D) transfer of cells back into the body after the gene transfer.
E) isolation and injection of normal proteins into patients.

F) A) and B)
G) None of the above

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MATCHING Match the appropriate term with the description. -DNA markers


A) Technique used to determine the location of a gene
B) Particular genes are often inherited jointly
C) Provides clues to the location of genes
D) A collection of DNA sequences that represents all regions of the genome
E) DNA sequences that are useful for identifying the positions of genes
F) Repetitive DNA with the ability to replicate and move around the genome
G) Map units of linkage maps
H) Repetitive sequences that are thought to have played an important role in human evolution
I) Genetic exchange between chromosomes
J) Repetitive sequences comprising about 17% of the genome

K) A) and H)
L) A) and D)

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