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Which of the following statements about estrogen is not true?


A) In low plasma concentration, estrogen inhibits pituitary secretion of LH and FSH
B) In high plasma concentration, estrogen stimulates pituitary sensitivity to GnRH
C) In the presence of high plasma concentration of progesterone, estrogen stimulates increased secretion of GnRH
D) Estrogen secretion is required for the LH surge
E) Estrogen stimulates follicular growth

F) A) and E)
G) All of the above

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Following crossing-over in Meiosis I - all of the following are true,except:


A) Maternal and paternal chromatids will always orient to opposite poles of the cell, remaining segregated from one another
B) Random orientation of maternal and parental chromatids to either pole of the cell allows mixing of these in resultant gametes
C) It is extremely unlikely that that all 23 maternal and paternal chromosomes will end up in the same gamete
D) A resulting gamete may have over eight million possible different combinations of maternal and paternal chromosomes
E) It is possible for one gamete to carry only maternal chromosomes or paternal chromosomes

F) A) and E)
G) A) and D)

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Atresia of all but the dominant follicle is a result of the diminished secretion of FSH during the second week of the follicular phase.

A) True
B) False

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Sexual differentiation of the embryo is normally determined by


A) The presence of two X chromosomes, which directs the undifferentiated gonads to develop into ovaries
B) The presence of the Y chromosome, which directs the undifferentiated gonads to develop into testes (when there is one X chromosome present as well)
C) Hormones produced by the placenta
D) Both the presence of two X chromosomes, which directs the undifferentiated gonads to develop into ovaries and hormones produced by the placenta
E) Both the presence of the Y chromosome, which directs the undifferentiated gonads to develop into testes (when there is one X chromosome present as well) and hormones produced by the placenta

F) A) and D)
G) None of the above

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In the differentiation of a normal female,


A) Müllerian inhibiting substance causes the Müllerian ducts to regress
B) The uterus and uterine tubes are formed from the Wolffian ducts
C) Female genitalia form in the absence of hormonal stimulation
D) The gonads remain undifferentiated throughout fetal life
E) None of the choices are true

F) A) and D)
G) A) and E)

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During pregnancy,placental lactogen serves to


A) Inhibit glucose utilization by maternal tissues
B) Promote breast growth
C) Increase maternal metabolism of fatty acids
D) Inhibit glucose utilization by maternal tissues and promote breast growth
E) Do all of these things

F) A) and D)
G) A) and E)

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Functions of estrogen during pregnancy include each of the following except


A) Stimulation of myometrial growth
B) Maintenance of the endometrium
C) Stimulation of prolactin secretion
D) Stimulation of breast development
E) Stimulation of milk synthesis

F) A) and D)
G) B) and E)

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Dysmenorrhea refers to pain or discomfort during menses.

A) True
B) False

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All steroid hormones act in the same general way; they bind with internal receptors,and then control the rate of formation of mRNA's called for to synthesize protein.

A) True
B) False

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The onset of puberty is triggered by an increase in


A) Sensitivity of the gonads to pituitary gonadotropins
B) Sensitivity of the pituitary to GnRH
C) GnRH secretion
D) Sensitivity of the gonads to pituitary gonadotropins and sensitivity of the pituitary to GnRH
E) All of the choices are correct

F) B) and C)
G) B) and E)

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Spermatogenesis


A) Begins with the mitotic division of a single spermatogonium
B) Results in four primary spermatocytes for every spermatogonium
C) Results in four spermatozoa for every primary spermatocyte
D) Both begins with the mitotic division of a single spermatogonium and results in four spermatozoa for every primary spermatocyte are correct
E) All of the choices are correct

F) A) and C)
G) A) and B)

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At ovulation,


A) The follicle ruptures
B) The second meiotic division of the oocyte occurs
C) The oocyte, along with its surrounding thecal layer, is expelled onto the ovarian surface
D) The follicle ruptures and the second meiotic division of the oocyte occurs
E) All of the choices occur

F) A) and D)
G) B) and E)

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The onset of puberty may be delayed indefinitely in girls who are very thin.

A) True
B) False

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Normally,only one sperm can fertilize an egg because


A) The first sperm to fuse with the oocyte plasma membrane triggers a process whereby enzymes begin to inactivate other nearby sperm
B) The first sperm to fuse with the oocyte plasma membrane triggers a process whereby the zona pellucida becomes impenetrable to other sperm
C) Only one sperm normally makes it to the vicinity of the egg
D) Only one sperm undergoes the acrosome reaction
E) Only one sperm undergoes capacitation

F) None of the above
G) A) and E)

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The placenta


A) Is an organ of nourishment for the embryo/fetus
B) Functions as the lungs and kidneys of the fetus prior to birth
C) Allows for mixing of fetal and maternal blood
D) Both is an organ of nourishment for the embryo/fetus and functions as the lungs and kidneys of the fetus prior to birth are correct
E) All of the choices are correct

F) All of the above
G) A) and E)

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Most of the hormonal effects on female accessory sex organs and secondary sex characteristics are attributable to progesterone.

A) True
B) False

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Menopause


A) Is the cessation of menstrual cycles
B) Results in low plasma levels of estrogens
C) Occurs as a result of cessation of gonadotropin secretion
D) Both is the cessation of menstrual cycles and results in low plasma levels of estrogens are correct
E) All of the choices are correct

F) A) and B)
G) B) and D)

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Which of the following statements is false?


A) Sperm formed in the testes enter the epididymis before entering the vas deferens
B) The seminal fluid is alkaline and rich in nutrients
C) The Sertoli cells produce androgen-binding protein
D) Sperm entering the epididymis are fully motile
E) Most of the seminal volume is provided by the secretions of the seminal vesicles and prostate gland

F) A) and C)
G) None of the above

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Which of the following organs can produce androgens?


A) Testes
B) Ovaries
C) Adrenal cortices
D) Both testes and ovaries are correct
E) All of the choices are correct

F) A) and D)
G) C) and D)

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Sertoli cells


A) Form a barrier between the blood and developing germ cells
B) Secrete inhibin
C) Protect spermatagonia from chemicals in the blood that might damage them
D) Both form a barrier between the blood and developing germ cells and secrete inhibin are correct
E) All of the choices are correct

F) A) and D)
G) C) and E)

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